PopSim Meeting

Location:
TBA

Start:
8 april 2021
8. april 2021 kl. 13:00

End:
8. april 2021 kl. 16:30

Model-based Insights into Complex Diseases assessed by Composite Scores

Many complex diseases such as Alzheimers Disease, Liver Diseases (NAFLD/NASH) and Prostatic Hyperplasia require a palette of clinical assessments, often including Patient Reported Outcomes (PRO), in order to characterise the spectre of disease symptoms. For diagnosis, evaluation of disease progression and treatment effects, clinical assessments are often integrated in one or more Composite Scores. This condensate rich multivariate data into single scales that are easier to work with in a clinical reality. However, the loss of information in Composite Scores present real challenges: How to interpret relative changes in scores over time and following treatment? How do scores relate to the underlying assessments? And to the patient perceived symptoms? At this PopSim meeting we will discuss model-based approaches to Composite Score analysis that may elevate the valuable information about the complexity of disease in underlying data.