PopSim – DRA symposium and workshops: Population PKPD modelling

Thursday 15 June – Friday 16 June 2023

The PopSim board and Drug Research Academy (DRA), under the University of Copenhagen host two workshops and a symposium around the implementation and application of population PKPD modelling in clinical research. We want to attract a broad audience to this meeting, so the program is tailored to both newcomers (for example master students, PhD students, clinicians and other researchers without modelling expertise) as well as established pharmacometricians. On the first day, we have an introduction to PKPD modelling for newcomers in the field. On the second day, we have a symposium in the morning with lectures on PBPK of large molecules, Clinical applications of PKPD modelling and PKPD modelling in the industrial setting and in the afternoon an advanced modelling workshop in nlmixr2. The advanced workshop can be attended after attending the beginner’s workshop, or it can be attended stand-alone for participants already familiar with pharmacometrics.

As this is a hands-on-workshop, participants will be required to bring a laptop and install R and nlmixr2 https://nlmixr2.org/ prior to the workshop.


Thursday 15 June 2023:
Venue: University of Copenhagen, Universitetsparken 4, 2100 Copenhagen, room U21

Workshop 1: introduction to PK/PD modelling
8.30 – 8.35: Welcome by Trine Meldgaard Lund
8.35 – 9:15: Lecture: Introduction to PK/PD modeling with basic examples using nlmixr2/rxode2
9:15 – 9:30: Coffee
9.30 – 10.30: Hands-on 1 in R: Understanding PK data, PK models and covariates
10:30 – 11:15: Lecture: Covariates and simulations
11:15 – 11.30: Coffee and sandwich
11:30 – 12:15: Hands-on 2 in R: Parameter estimations and model diagnostics
12:15 – 12:30: Closing remarks

Lectures and hand-on sessions by the PopSim board members: Theodoros Papathanasiou, Daniël Jonker, Eva Sverrisdóttir, Rasmus Juul Kildemoes, Trine Meldgaard Lund

Friday 16 th of June 2023:
Venue: Ferring Pharmaceuticals, Amager Strandvej 405, 2770 Kastrup

Symposium chaired by Trine Meldgaard Lund and Daniël Jonker
9:00 – 9:25: Arrival and coffee
9:25 – 9:30: Welcome by Daniël Jonker
9:30 – 10:15: Principles and Application of PBPK modelling for large molecules by Senior Research Scientist Felix Stader (Certara, UK)
10:20 – 11:05: Clinical applications of population PKPD modelling to guide dosing in special patient populations: examples in neonates and obese patients by Professor Catherijne Knibbe (Leiden University, NL)
11:10 – 11:55 PKPD modelling in an industrial setting by Modelling Director Rune Overgaard (Pharmacometrics, Novo Nordisk, DK)
12:00 – 13:00 Lunch

Workshop 2: nlmixr2
13:00 – 16:00: Hands-on in R: An advanced workshop in nlmixr2 by Rik Schoemaker (Occams, Netherlands) and Theodoros Papathanasiou (GSK)

It is necessary to pre-register for either day 1, day 2 morning or day 2 afternoon or a combination of these. The lunch is open to symposium attendees only. REGISTRATION before 16 May 2023

PopSim Sektionen for Kvantitativ Farmakologi (PopSim) – Danmarks Farmaceutiske Selskab (farmaceutisk-selskab.dk) DRA About the Drug Research Academy – University of Copenhagen (ku.dk)

On behalf of the PopSim board and DRA

Daniël Jonker, Theodoros Papathanasiou, Rasmus Juul Kildemoes, Eva Sverrisdóttir and Trine Meldgaard Lund


15. June – 08:30

16. June – 16:00


Sign up

Register here before May 16th.