Møde: The Blood Brain Barrier

Please register by mail to pd(at)pharmadanmark.dk before the 22nd of march 2010

Getting drug into the brain to achieve clinical effect or avoid the entrance to
circumvent possible side effects is a natural part of drug discovery and
development, which biologically is defined by the compounds ability to cross the
blood-brain barrier (BBB)

The BBB is a separation of circulating blood and cerebrospinal fluid (CSF)
maintained by the choroid plexus in the central nervous system (CNS). Endothelial
cells restrict the diffusion of microscopic objects (e.g. bacteria) and large or
hydrophilic molecules into the CSF, while allowing the diffusion of small
hydrophobic molecules (O2, hormones, CO2). Cells of the barrier actively transport
metabolic products such as glucose across the barrier with specific proteins.

This "barrier" results from the selectivity of the tight junctions between
endothelial cells in CNS vessels that restrict the passage of solutes - including
drugs, hence understanding the BBB is important to develop drugs for the treatment of these diseases. This meeting will provide an overview of the physiology of the BBB and a presentation of the current research both from an academia and from an industrial point of view.

Dato

25.03.2010

Nr.

44

Tid

14:00–16:30

Sted

Benzon auditoriet

Det Farmaceutiske Fakultet, Københavns Universitet, Universitetsparken 2, 2100 København Ø

Tid og sted

Faculty of Pharmaceutical Sciences
University of Copenhagen
Universitetsparken 2
Copenhagen OE

Foredragsholdere

René Holm, H.Lundbeck A/S

Torben Moos, Professor, Aalborg University

Birger Brodin, Associate Professor, Copenhagen University

Lassina Badolo, Dr., H.Lundbeck A/S

Pris

Gratis

Arrangør

Biofarmaci

Frist for tilmelding

22.02.2010

Tilmelding

ingen registrering er nødvendig til dette arrangement

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